Each capsule contains Amoxycillin Trihydrate equivalent to 500 mg Amoxycillin.
Amoxycillin is amino penicillin with actions and uses very similar to those of ampicillin Absorption
from the gastrointestinal tract is better than for ampicillin and is less affected by food. Adverse effects
are similar although the incidence of diarrhoea may be less with amoxycillin.
Treatment of infections caused by penicillin-sensitive Gram-positive bacteria as well as H, Influenzas,
E Coli, P Mirabilis, Salmonella and some Shigellosis species. Treatment of bronchitis, otitis media.
bacterial pharyngitis, bacterial pneumonia, sinusitis, urinary tract infections.
Known history of hypcrsensitivity or allergic reactions to any of the penicillins.
Side effects/Adverse Reactions:
More frequent(more than 10%) gastrointestinal reactions(mild diarrhoea nausea or vomiting),
exfoliative dermatitis, serum sickness-like reactions, skin rash, hives, itching. Rare(0001-1%-9)
headache, oral candidiasis, vaginal candidiasis. Occasional(1-3%): Allergic reactions(anaphylax
Clostridium difficile colitis(may occur up to several weeks after discontinuation of the medication),
interstitial nephritis, leukopenia, neutropenia, or thrombocytopenia, seizures(in patients receiving high
doses and/or having a renal function impairment).
Patients allergic to one penicillin may be allergicto other penicillins also Penicillins are distributed into
breast milk. Although significant problems have not been documented, the use of penicillins in nursing
mothers may lead to sensitisation, diarrhoea, candidiasis and skin rash in the infant
Dosage and Administration:
Capsules: 500mg every eight hours. The usual adult prescribing limits are 4, 5 g a day.
bacterial endocarditis, meningitis or septicaemia I to 2 every 3 to 4 hours; listeriosis 50 mg per kg of
body weight 6 hours. Neonates up to 2 kgof body weight 25 to 50 mg every 12 hours during the
first week of life thereafter 50 mg every eight hours. Nconates over 2 kg 50 mgper kg of body weight
every 8 hours during the first week of life thereafter every six hours. Infant up to 20 kg 12, 5 mg per kg
of body weight every 6 hours. Infant over 20 kg should receive the usual adult dose.
There is no specific antidote for amoxycillin. Treatment is primarily symptomatic and supportive.
Decrease absorption(induction of emesis or gastric lavage, multiple doses of charcoal), enhance
elimination( dialysis is indicated to aid the removal of penicillins from the blood), monitor and give
Store below 25ºC.
for Export use only